Error message while trying to flash the FYSETEC S6 V2.1 with STM32CuveProgrammer

[pilleway]

Hi to all.
Help will be advance appreciated.
My project is a OnStep conversion for my telescope to replace DC motors with Step motors.
Trying to flash my board I get the following meesage,
14:39:33 : RTS low
14:39:33 : DTR low
14:39:33 : Serial Port COM6 is successfully opened.
14:39:33 : Port configuration: parity = none, baudrate = 9600, data-bit = 8, stop-bit = 1.0, flow-control = off
14:39:35 : Timeout error occured while waiting for acknowledgement.
14:39:35 : Timeout error occured while waiting for acknowledgement.
14:39:35 : Error: Activating device: KO. Please, verify the boot mode configuration and check the serial port configuration. Reset your device then try again...
As it says port is oppen, but do not know what to do! I looked to assure the jumper in BOOT0 was porperly done, also have 5v thrugh USB, verified cable connection, Also I had reinstalled SMT32CubeProgrammer, all my thoughts to define the problem had exausted.
As you can see, I'm very limited and would like to flash the board and get to next step, to be able to do bench test.
All recomendations and help will be appreciated.
Miguel.

[pilleway]

The instruccions I have followe are OnStep instrucctions "For the STM32F446 FYSETC S6:" on https://onstep.groups.io/g/main/wiki/3915

Regards